Zoloft Zoloft. Drug and Patient Information. Dosage. Overdose. Generic or Brand Zoloft. For Professionals and Consumers. Zoloft is prescribed for major depressive disorder, a persistently low mood that interferes with everyday living. Symptoms may include loss of interest in your usual activities, disturbed sleep, change in appetite, constant fidgeting or lethargic movement, fatigue, feelings of [...]